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Genomic Medicine Overview

The Evolution of Genomic Medicine

Completion of the Human Genome Project and growing knowledge of gene function has led to an ever-broadening application of genomic information in clinical practice. As genomic platforms improve, so does the ability to identify the genomic fingerprints or signatures of common, complex diseases at molecular and cellular levels. Genomic medicine delivers a more complete picture of an individual patient’s disease state by combining information about what’s currently happening in the patient’s body with information from traditional, noninvasive methods. With this information, you are able to make more individualized patient care decisions.

Gene Expression Testing vs. Genetic Testing

Corus® CAD is a gene expression test and not a genetic test. Genetic tests determine DNA sequence or detect polymorphisms, which stay constant throughout a person’s lifetime and can help estimate a person’s risk of developing disease in the future. Because the likelihood of a person developing any given disease is significantly influenced by both the person’s genetic make-up (DNA) and environment (diet, exercise, stress, other lifestyle factors), genetic tests alone cannot tell whether a person will ever develop disease. In contrast, the Corus CAD gene expression test provides information about a person’s current disease state because it measures the activity of specific RNAs known to be involved in the response to and development and progression of atherosclerosis. RNA levels change as a result of disease processes happening inside a person’s body and can be used to inform on current disease status.